CLEANING IN PLACE (CIP) Module is the process used to ensure that, process reactors, vessels and lines are free of organic and inorganic contaminants:

Application :

Pharmaceuticals

• Sterile Solutions

• Vial

• Ampoules

• I. V. Fluids

• Aerosols

• LVP & SVP Solutions

• Vaccines

• Human Insulin

• Serums

• Plasma Fractions

• Bacteria and cell cultures

CIP cycles can be subjected to the following process machinery

• Fermentors

• Blending Vessels

• Media / Harvest / Storage / Filtration Vessels

• Transfer Lines

• Process Equipment

• Completely Automated Process Cycles

• On line display of process parameters with P & I of Operating
Systems

• Display of Fault messages

• Supervisory access code prevent unauthorized changes

• Detergent / Acid / Alkali dosing

• On Line pH, Conductivity, TOC Sensing

• CIP is designed in accordance with ASME BPE and EHEDG guidelines

• PLC-based, with Touch Screen MMI and SCADA Packages

Key Benefits:

• Validatable process for Sterilization of process equipment

• Lower Facility Operating Costs

• Minimal dismantling of equipment and piping

• Reduced turnaround time for cleaning

• WFI requirement for cleaning reduced significantly

• Exposure to hazardous activities or entry into tanks, is eliminated

Spray device characteristics

• The cleaning liquid turns the spray head by means of a specially
positioned nozzle

• Rapid repitition impact loosens the dirt and washes it off the tank
surface

• The cleaning effects is optimum at low pressure in small to medium
size tanks

• With increasing pressure, the rotation speed gets higher, while due
to stronger atomization, the reach of the spray gets lower

• Operation at the optimum pressure ensures required cleaning results
and avoids wear of the nozzle

Effective Cleaning Criteria Factors include

• Cleaning Cycle Time

• Cleaning Agent and Temperature

• Concentration and Chemistry of the Cleaning Agent within the circuit

• Degree of Turbulence of the Cleaning Solution

• Characteristics of the surface being cleaned

• Spray Device Selection (Static Dynamic)

Capacity

• CIP Module for Processing Vessels ranging from 50 litres to 30000 litres