CIP is the process used to ensure that, process reactors, vessels and lines are free of organic and inorganic contaminants:
Application :
Pharmaceuticals
- • Sterile Solutions
- • Vial
- • Ampoules
- • I. V. Fluids
- • Aerosols
- • LVP & SVP Solutions
- • Vaccines
- • Human Insulin
- • Serums
- • Plasma Fractions
- • Bacteria and cell cultures
CIP cycles can be subjected to the following process machinery
- • Fermentors
- • Blending Vessels
- • Media / Harvest / Storage / Filtration Vessels
- • Transfer Lines
- • Process Equipment
- • Completely Automated Process Cycles
- • On line display of process parameters with P & I of Operating
Systems - • Display of Fault messages
- • Display of Fault messages
- • Supervisory access code prevent unauthorized changes
- • Detergent / Acid / Alkali dosing
- • On Line pH, Conductivity, TOC Sensing
- • CIP is designed in accordance with ASME BPE and EHEDG guidelines
- • PLC-based, with Touch Screen MMI and SCADA Packages
Key Benefits:
- • Validatable process for Sterilization of process equipment
- • Lower Facility Operating Costs
- • Minimal dismantling of equipment and piping
- • Reduced turnaround time for cleaning
- • WFI requirment for cleaning reduced significantly
- • Exposure to hazardous activities or entry into tanks, is eliminated
Spray device characteristics
- • The cleaning liquid turns the spray head by means of a speciallypositioned nozzle
- • Rapid epetition impact loosens the dirt and washes it off the tanksurface
- • The cleaning effects is optimum at low pressure in small to mediumsize tanks
- • With increasing pressure, the rotation speed gets highre, while dueto stronger atomization, the reach of the spray gets lower
- • Operation at the optimum pressure ensures required cleaning resultsand avoids wear of the nozzle
Effective Cleaning Criteria Factors include
- • Cleaning Cycle Time
- • Cleaning Agent and Temperature
- • Concentration and Chemistry of the Cleaning Agent within the circuit
- • Degree of Turbulence of the Cleaning Solution
- • Characteristics of the surface being Cleaned
- • Spray Device Selection (Static Dynamic)
Capacity
- • CIP Module for Processing Vessels ranging from 50 litres to 30000 litres