CLEANING IN PLACE (CIP) Module is the process used to ensure that, process reactors, vessels and lines are free of organic and inorganic contaminants:

Application :



Pharmaceuticals

• Sterile Solutions
• Vial
• Ampoules
• I. V. Fluids
• Aerosols
• LVP & SVP Solutions
Biopharmaceuticals
• Vaccines
• Human Insulin
• Serums
• Plasma Fractions
• Bacteria and cell cultures

CIP cycles can be subjected to the following process machinery

• Fermentors
• Blending Vessels
• Media / Harvest / Storage / Filtration Vessels
• Transfer Lines
• Process Equipment
Technical Highlights
• Completely Automated Process Cycles
• On line display of process parameters with P & I of Operating
Systems
• Display of Fault messages
• Supervisory access code prevent unauthorized changes
• Detergent / Acid / Alkali dosing
• On Line pH, Conductivity, TOC Sensing
• CIP is designed in accordance with ASME BPE and EHEDG guidelines
• PLC-based, with Touch Screen MMI and SCADA Packages

Key Benefits:

• Validatable process for Sterilization of process equipment
• Lower Facility Operating Costs
• Minimal dismantling of equipment and piping
• Reduced turnaround time for cleaning
• WFI requirement for cleaning reduced significantly
• Exposure to hazardous activities or entry into tanks, is eliminated






Spray device characteristics

• The cleaning liquid turns the spray head by means of a specially
positioned nozzle
• Rapid repitition impact loosens the dirt and washes it off the tank
surface
• The cleaning effects is optimum at low pressure in small to medium
size tanks
• With increasing pressure, the rotation speed gets higher, while due
to stronger atomization, the reach of the spray gets lower
• Operation at the optimum pressure ensures required cleaning results
and avoids wear of the nozzle

Effective Cleaning Criteria Factors include

• Cleaning Cycle Time
• Cleaning Agent and Temperature
• Concentration and Chemistry of the Cleaning Agent within the circuit
• Degree of Turbulence of the Cleaning Solution
• Characteristics of the surface being cleaned
• Spray Device Selection (Static Dynamic)

Capacity

• CIP Module for Processing Vessels ranging from 50 litres to 30000 litres
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